The BioMind Lab At the University of Cambridge and University of Oxford

Publications

BioMind team research, reviews and pre-registrations

Highlighted

Immune dysfunction in psychiatric disorders: emerging genomic insights
Immune dysfunction in psychiatric disorders: emerging genomic insights
Isabelle M McGrath, Mary-Ellen Lynall
Current Opinion in Genetics & Development  ·  01 Jun 2026  ·  doi:10.1016/j.gde.2026.102467
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Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, …, Joel Gelernter, Murray B. Stein, Gosia Trynka, Menna R. Clatworthy, Ed Bullmore
Nature Communications  ·  15 Oct 2022  ·  doi:10.1038/S41467-022-33885-7
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, …, Ferenc Livak, Abdel G. Elkahloun, Menna R. Clatworthy, Edward T. Bullmore, Miles Herkenham
Nature Communications  ·  01 Sep 2025  ·  doi:10.1038/s41467-025-62840-5
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Mary-Ellen Lynall, Lorinda Turner, Junaid Bhatti, Jonathan Cavanagh, Peter de Boer, …, Neil A Harrison, Carmine M Pariante, Linda Pointon, Menna R Clatworthy, Edward Bullmore
Biological psychiatry  ·  02 Dec 2019  ·  pmid:32000983

All

2026

Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives.
Immune dysregulation in depression and psychosis: summary of current evidence and future perspectives.
Tomas Formanek, Mary-Ellen Lynall, Emanuele Felice Osimo
The British journal of psychiatry : the journal of mental science  ·  08 Sep 2026  ·  pmid:42708395
Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression
Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression
Laurence Nisbet, Yang Wu, Mark Adams, Mary-Ellen Lynall, Jens Hjerling-Leffler, Naomi R. Wray, Andrew M. McIntosh, Xueyi Shen
Biological Psychiatry  ·  01 Jun 2026  ·  doi:10.1016/J.BIOPSYCH.2025.11.024
Systematic Review and Mega-Analysis of the Peripheral Blood Transcriptome in Depression Implicates Dysregulation of Lymphoid Cells and Histones
Systematic Review and Mega-Analysis of the Peripheral Blood Transcriptome in Depression Implicates Dysregulation of Lymphoid Cells and Histones
Chaitanya Erady, Richard Bethlehem, Edward Bullmore, Mary-Ellen Lynall
Biological Psychiatry  ·  01 Jun 2026  ·  doi:10.1016/j.biopsych.2025.09.008
Immune dysfunction in psychiatric disorders: emerging genomic insights
Immune dysfunction in psychiatric disorders: emerging genomic insights
Isabelle M McGrath, Mary-Ellen Lynall
Current Opinion in Genetics & Development  ·  01 Jun 2026  ·  doi:10.1016/j.gde.2026.102467
NMDAR subunit GluN1 dynamics in urinary astrocyte-derived extracellular vesicles in anti-NMDAR encephalitis
NMDAR subunit GluN1 dynamics in urinary astrocyte-derived extracellular vesicles in anti-NMDAR encephalitis
Junhua Mei, Mian-mian Chen, Qing Yang, Shu-xian Xu, Chao Wang, …, Qian Gong, Zhongchun Liu, Edward Bullmore, Mary-Ellen Lynall, Xin-hui Xie
openRxiv  ·  31 Mar 2026  ·  doi:10.64898/2026.03.30.26349276
Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder
Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder
Alicia Walker, Brittany L. Mitchell, Tian Lin, Jacob J. Crouse, Clara Albiñana, …, Sarah E. Medland, Nicholas G. Martin, Maxime Taquet, Ian B. Hickie, Naomi R. Wray
JAMA Psychiatry  ·  01 Mar 2026  ·  doi:10.1001/JAMAPSYCHIATRY.2025.4372

2025

Inflammatory profiles of transdiagnostic symptom dimensions in healthy females
Inflammatory profiles of transdiagnostic symptom dimensions in healthy females
Alicia J. Smith, Stacey Kigar, Quentin Dercon, Mary-Ellen Lynall, Konstantinos Ioannidis, Muzaffer Kaser, Caitlin Hitchcock, Tim Dalgleish, Camilla L. Nord
Brain, Behavior, & Immunity - Health  ·  01 Dec 2025  ·  doi:10.1016/J.BBIH.2025.101146
Systematic Review and Mega-Analysis of the Peripheral Blood Transcriptome in Depression Implicates Dysregulation of Lymphoid Cells and Histones.
Systematic Review and Mega-Analysis of the Peripheral Blood Transcriptome in Depression Implicates Dysregulation of Lymphoid Cells and Histones.
Chaitanya Erady, Richard Bethlehem, Edward Bullmore, Mary-Ellen Lynall
Elsevier  ·  03 Oct 2025  ·  doi:10.17863/cam.121913
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, …, Ferenc Livak, Abdel G. Elkahloun, Menna R. Clatworthy, Edward T. Bullmore, Miles Herkenham
Nature Communications  ·  01 Sep 2025  ·  doi:10.1038/s41467-025-62840-5
The Psychiatric Genomics Consortium: discoveries and directions.
The Psychiatric Genomics Consortium: discoveries and directions.
Arpana Agrawal, Cynthia M Bulik, Dawit Shawel Abebe, Ole A Andreassen, Elizabeth G Atkinson, …, Biju Viswanath, James T R Walters, Hyejung Won, Naomi R Wray, Patrick F Sullivan
The lancet. Psychiatry  ·  26 Jun 2025  ·  pmid:40582370
How does cancer affect motivation
How does cancer affect motivation?
Jeffrey W Dalley, Mary-Ellen Lynall
Science (New York, N.Y.)  ·  10 Apr 2025  ·  pmid:40209005
The Psychiatric Genomics Consortium: discoveries and directions
The Psychiatric Genomics Consortium: discoveries and directions
Elsevier  ·  01 Jan 2025  ·  doi:10.17615/79bv-9572
Specific immunological pathways in psychosis: Protocol for an in-silico, hypothesis-driven analysis
Specific immunological pathways in psychosis: Protocol for an in-silico, hypothesis-driven analysis
Mary-Ellen Lynall, John F. W. Deakin, Emanuele F Osimo, Benjamin Perry, Suleyman Noordeen, Stephen Burgess, Neha Abraham, Graham Murray
OSF  ·  01 Jan 2025  ·  doi:10.17605/osf.io/yu32e
DEPICT: Depression, epigenetics, and childhood trauma
DEPICT: Depression, epigenetics, and childhood trauma
Mary-Ellen Lynall, Stacey Kigar, Ed Bullmore, Simon White, Eric Miska
OSF Registries  ·  01 Jan 2025  ·  doi:10.17605/osf.io/eydvh

2024

Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.
Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.
Alicia J Smith, James A Bisby, Quentin Dercon, Anna Bevan, Stacey L Kigar, Mary-Ellen Lynall, Tim Dalgleish, Caitlin Hitchcock, Camilla L Nord
Translational psychiatry  ·  04 Mar 2024  ·  pmid:38438352

2023

The Heterogeneity of Depression.
The Heterogeneity of Depression.
Mary-Ellen Lynall, Andrew M McIntosh
The American journal of psychiatry  ·  01 Oct 2023  ·  pmid:37777851
Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.
Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.
Ethan G Dutcher, Laura Lopez-Cruz, E A Claudia Pama, Mary-Ellen Lynall, Iris C R Bevers, …, Amy L Milton, Menna R Clatworthy, Trevor W Robbins, Edward T Bullmore, Jeffrey W Dalley
Translational psychiatry  ·  07 Mar 2023  ·  pmid:36882404

2022

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, …, Joel Gelernter, Murray B. Stein, Gosia Trynka, Menna R. Clatworthy, Ed Bullmore
Nature Communications  ·  15 Oct 2022  ·  doi:10.1038/S41467-022-33885-7

2021

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Miruna C. Barbu, Floris Huider, Archie Campbell, Carmen Amador, Mark J. Adams, …, Edward Bullmore, Gonneke Willemsen, Dorret I. Boomsma, Heather C. Whalley, Andrew M. McIntosh
Molecular Psychiatry  ·  08 Dec 2021  ·  doi:10.1038/S41380-021-01412-7
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Athina R Aruldass, Manfred G Kitzbichler, Sarah E Morgan, Sol Lim, Mary-Ellen Lynall, …, Jonathan Cavanagh, Phil Cowen, Carmine M Pariante, Neil A Harrison, Edward T Bullmore
Brain, behavior, and immunity  ·  25 Aug 2021  ·  pmid:34450247
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
Mary-Ellen Lynall, Stacey L Kigar, Michael L Lehmann, Allison E DePuyt, Zewen Kelvin Tuong, Samuel J Listwak, Abdel G Elkahloun, Edward T Bullmore, Miles Herkenham, Menna R Clatworthy
Brain, behavior, and immunity  ·  08 Aug 2021  ·  pmid:34371135
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
Elsevier  ·  06 Aug 2021  ·  doi:10.17863/cam.73874
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
John J Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J Cowen, …, Carmine Pariante, Linda Pointon, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Translational psychiatry  ·  22 Jul 2021  ·  pmid:34294682

2020

Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.
Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.
Ethan G Dutcher, E A Claudia Pama, Mary-Ellen Lynall, Shahid Khan, Menna R Clatworthy, Trevor W Robbins, Edward T Bullmore, Jeffrey W Dalley
Brain and neuroscience advances  ·  28 Dec 2020  ·  pmid:33447663
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.
Emanuele F Osimo, Benjamin I Perry, Rudolf N Cardinal, Mary-Ellen Lynall, Jonathan Lewis, Arti Kudchadkar, Graham K Murray, Jesus Perez, Peter B Jones, Golam M Khandaker
Brain, behavior, and immunity  ·  17 Sep 2020  ·  pmid:32950620

2019

Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Mary-Ellen Lynall, Lorinda Turner, Junaid Bhatti, Jonathan Cavanagh, Peter de Boer, …, Neil A Harrison, Carmine M Pariante, Linda Pointon, Menna R Clatworthy, Edward Bullmore
Biological psychiatry  ·  02 Dec 2019  ·  pmid:32000983
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Renzo Mancuso, Gemma Fryatt, Madeleine Cleal, Juliane Obst, Elena Pipi, …, Howard Mount, Declan N C Jones, Simon Lovestone, Diego Gómez-Nicola, V Hugh Perry
Brain  ·  26 Aug 2019  ·  doi:10.1093/BRAIN/AWZ241
Inflammatory biomarkers in Alzheimer s disease plasma
Inflammatory biomarkers in Alzheimer's disease plasma
Angharad R. Morgan, Samuel Touchard, Claire Leckey, Caroline O’Hagan, Alejo J. Nevado‐Holgado, …, Anders Wallin, Sarah Westwood, Henrik Zetterberg, Simon Lovestone, B. Paul Morgan
Alzheimer's & Dementia  ·  29 Apr 2019  ·  doi:10.1016/J.JALZ.2019.03.007

2018

Neuropsychiatric symptoms in lupus.
Neuropsychiatric symptoms in lupus.
M Lynall
Lupus  ·  01 Oct 2018  ·  pmid:30452327

2016

Detection of functional brain network reconfiguration during task-driven cognitive states.
Detection of functional brain network reconfiguration during task-driven cognitive states.
Qawi K Telesford, Mary-Ellen Lynall, Jean Vettel, Michael B Miller, Scott T Grafton, Danielle S Bassett
NeuroImage  ·  31 May 2016  ·  pmid:27261162

2015

Cognitive network neuroscience.
Cognitive network neuroscience.
John D Medaglia, Mary-Ellen Lynall, Danielle S Bassett
Journal of cognitive neuroscience  ·  24 Mar 2015  ·  pmid:25803596
Brain network adaptability across task states.
Brain network adaptability across task states.
Elizabeth N Davison, Kimberly J Schlesinger, Danielle S Bassett, Mary-Ellen Lynall, Michael B Miller, Scott T Grafton, Jean M Carlson
PLoS computational biology  ·  08 Jan 2015  ·  pmid:25569227

2013

Immunologic therapeutics and psychotic disorders.
Immunologic therapeutics and psychotic disorders.
Edward T Bullmore, Mary-Ellen Lynall
Biological psychiatry  ·  21 Dec 2013  ·  pmid:24439554

2010

Functional Connectivity and Brain Networks in Schizophrenia
Functional Connectivity and Brain Networks in Schizophrenia
M.-E. Lynall, D. S. Bassett, R. Kerwin, P. J. McKenna, M. Kitzbichler, U. Muller, E. Bullmore
Journal of Neuroscience  ·  14 Jul 2010  ·  doi:10.1523/JNEUROSCI.0333-10.2010