The BioMind Lab At the University of Cambridge and University of Oxford

Research

Group publications and previous work by M Lynall that has influenced our team’s focus.

Highlighted

Systematic review and mega-analysis of the peripheral blood transcriptome in depression implicates dysregulation of lymphoid cells and histones
Systematic review and mega-analysis of the peripheral blood transcriptome in depression implicates dysregulation of lymphoid cells and histones
Chaitanya Erady, Richard A.I. Bethlehem, Ed T Bullmore, Mary-Ellen Lynall
Cold Spring Harbor Laboratory  ·  05 May 2025  ·  doi:10.1101/2025.05.01.25326802
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, …, Joel Gelernter, Murray B. Stein, Gosia Trynka, Menna R. Clatworthy, Ed Bullmore
Nature Communications  ·  15 Oct 2022  ·  doi:10.1038/s41467-022-33885-7
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, …, Ferenc Livak, Abdel G. Elkahloun, Menna R. Clatworthy, Edward T. Bullmore, Miles Herkenham
Cold Spring Harbor Laboratory  ·  31 Aug 2024  ·  doi:10.1101/2024.08.30.610447
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Mary-Ellen Lynall, Lorinda Turner, Junaid Bhatti, Jonathan Cavanagh, Peter de Boer, …, Neil A Harrison, Carmine M Pariante, Linda Pointon, Menna R Clatworthy, Edward Bullmore
Biological psychiatry  ·  02 Dec 2019  ·  pmid:32000983

All

2025

Systematic review and mega-analysis of the peripheral blood transcriptome in depression implicates dysregulation of lymphoid cells and histones
Systematic review and mega-analysis of the peripheral blood transcriptome in depression implicates dysregulation of lymphoid cells and histones
Chaitanya Erady, Richard A.I. Bethlehem, Ed T Bullmore, Mary-Ellen Lynall
Cold Spring Harbor Laboratory  ·  05 May 2025  ·  doi:10.1101/2025.05.01.25326802
How does cancer affect motivation
How does cancer affect motivation?
Jeffrey W Dalley, Mary-Ellen Lynall
Science (New York, N.Y.)  ·  10 Apr 2025  ·  pmid:40209005
The Psychiatric Genomics Consortium: Discoveries and Direction
The Psychiatric Genomics Consortium: Discoveries and Direction
Arpana Agrawal, Cynthia Bulik, Dawit Shawel Abebe, Ole Andreassen, Elizabeth Atkinson, …, Biju Viswanath, James Walters, Hyejung Won, Lu Yi, Patrick Sullivan
[no publisher info]  ·  01 Jan 2025  ·  ppr:PPR973163

2024

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling
Stacey L. Kigar, Mary-Ellen Lynall, Allison E. DePuyt, Robert Atkinson, Virginia H. Sun, …, Ferenc Livak, Abdel G. Elkahloun, Menna R. Clatworthy, Edward T. Bullmore, Miles Herkenham
Cold Spring Harbor Laboratory  ·  31 Aug 2024  ·  doi:10.1101/2024.08.30.610447
Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.
Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.
Alicia J Smith, James A Bisby, Quentin Dercon, Anna Bevan, Stacey L Kigar, Mary-Ellen Lynall, Tim Dalgleish, Caitlin Hitchcock, Camilla L Nord
Translational psychiatry  ·  04 Mar 2024  ·  pmid:38438352

2023

The Heterogeneity of Depression.
The Heterogeneity of Depression.
Mary-Ellen Lynall, Andrew M McIntosh
The American journal of psychiatry  ·  01 Oct 2023  ·  pmid:37777851
Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.
Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.
Ethan G Dutcher, Laura Lopez-Cruz, E A Claudia Pama, Mary-Ellen Lynall, Iris C R Bevers, …, Amy L Milton, Menna R Clatworthy, Trevor W Robbins, Edward T Bullmore, Jeffrey W Dalley
Translational psychiatry  ·  07 Mar 2023  ·  pmid:36882404

2022

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, …, Joel Gelernter, Murray B. Stein, Gosia Trynka, Menna R. Clatworthy, Ed Bullmore
Nature Communications  ·  15 Oct 2022  ·  doi:10.1038/s41467-022-33885-7

2021

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Miruna C. Barbu, Floris Huider, Archie Campbell, Carmen Amador, Mark J. Adams, …, Edward Bullmore, Gonneke Willemsen, Dorret I. Boomsma, Heather C. Whalley, Andrew M. McIntosh
Molecular Psychiatry  ·  08 Dec 2021  ·  doi:10.1038/s41380-021-01412-7
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression.
Athina R Aruldass, Manfred G Kitzbichler, Sarah E Morgan, Sol Lim, Mary-Ellen Lynall, …, Jonathan Cavanagh, Phil Cowen, Carmine M Pariante, Neil A Harrison, Edward T Bullmore
Brain, behavior, and immunity  ·  25 Aug 2021  ·  pmid:34450247
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.
Mary-Ellen Lynall, Stacey L Kigar, Michael L Lehmann, Allison E DePuyt, Zewen Kelvin Tuong, Samuel J Listwak, Abdel G Elkahloun, Edward T Bullmore, Miles Herkenham, Menna R Clatworthy
Brain, behavior, and immunity  ·  08 Aug 2021  ·  pmid:34371135
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
John J Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J Cowen, …, Carmine Pariante, Linda Pointon, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Translational psychiatry  ·  22 Jul 2021  ·  pmid:34294682

2020

Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.
Early-life stress and inflammation: A systematic review of a key experimental approach in rodents.
Ethan G Dutcher, E A Claudia Pama, Mary-Ellen Lynall, Shahid Khan, Menna R Clatworthy, Trevor W Robbins, Edward T Bullmore, Jeffrey W Dalley
Brain and neuroscience advances  ·  28 Dec 2020  ·  pmid:33447663
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.
Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.
Emanuele F Osimo, Benjamin I Perry, Rudolf N Cardinal, Mary-Ellen Lynall, Jonathan Lewis, Arti Kudchadkar, Graham K Murray, Jesus Perez, Peter B Jones, Golam M Khandaker
Brain, behavior, and immunity  ·  17 Sep 2020  ·  pmid:32950620
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune syste
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune syste
MC Barbu, F. Huider, A. Campbell, C. Amador, MJ Adams, …, E. Bullmore, G. Willemsen, DI Boomsma, HC Whalley, AM McIntosh
[no publisher info]  ·  01 Jan 2020  ·  ppr:PPR222070

2019

Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.
Mary-Ellen Lynall, Lorinda Turner, Junaid Bhatti, Jonathan Cavanagh, Peter de Boer, …, Neil A Harrison, Carmine M Pariante, Linda Pointon, Menna R Clatworthy, Edward Bullmore
Biological psychiatry  ·  02 Dec 2019  ·  pmid:32000983

2018

Neuropsychiatric symptoms in lupus.
Neuropsychiatric symptoms in lupus.
M Lynall
Lupus  ·  01 Oct 2018  ·  pmid:30452327

2016

Detection of functional brain network reconfiguration during task-driven cognitive states.
Detection of functional brain network reconfiguration during task-driven cognitive states.
Qawi K Telesford, Mary-Ellen Lynall, Jean Vettel, Michael B Miller, Scott T Grafton, Danielle S Bassett
NeuroImage  ·  31 May 2016  ·  pmid:27261162

2015

Cognitive network neuroscience.
Cognitive network neuroscience.
John D Medaglia, Mary-Ellen Lynall, Danielle S Bassett
Journal of cognitive neuroscience  ·  24 Mar 2015  ·  pmid:25803596
Brain network adaptability across task states.
Brain network adaptability across task states.
Elizabeth N Davison, Kimberly J Schlesinger, Danielle S Bassett, Mary-Ellen Lynall, Michael B Miller, Scott T Grafton, Jean M Carlson
PLoS computational biology  ·  08 Jan 2015  ·  pmid:25569227

2013

Immunologic therapeutics and psychotic disorders.
Immunologic therapeutics and psychotic disorders.
Edward T Bullmore, Mary-Ellen Lynall
Biological psychiatry  ·  21 Dec 2013  ·  pmid:24439554

2010

Functional Connectivity and Brain Networks in Schizophrenia
Functional Connectivity and Brain Networks in Schizophrenia
M.-E. Lynall, D. S. Bassett, R. Kerwin, P. J. McKenna, M. Kitzbichler, U. Muller, E. Bullmore
Journal of Neuroscience  ·  14 Jul 2010  ·  doi:10.1523/JNEUROSCI.0333-10.2010